Cognitive Reflection Test (CRT) Practice

What adverse effect is most likely to occur with dopamine agonists used in Parkinson's disease?

1. Restlessness

2. Weight gain

3. Orthostatic hypotension

4. Increased appetite

The correct answer is: Orthostatic hypotension

Dopamine agonists, commonly used in the treatment of Parkinson's disease, can lead to orthostatic hypotension, which is characterized by a significant drop in blood pressure when a person stands up. This occurs due to the medications affecting the autonomic nervous system and can lead to symptoms such as dizziness, lightheadedness, and fainting upon standing. The association with orthostatic hypotension is particularly relevant because patients with Parkinson's disease already experience autonomic dysfunction, and adding dopamine agonists can exacerbate this condition. Recognizing this potential side effect is crucial for patient safety and management, as it impacts daily activities and mobility. While restlessness, weight gain, and increased appetite can be considerations with some medications, they are not as directly linked to the pharmacological effects of dopamine agonists in the same way that orthostatic hypotension is. Understanding this helps patients and healthcare providers to better monitor and manage the effects of treatment for Parkinson's disease.